The Innate Mononuclear Phagocyte Network Depletes B Lymphocytes through Fc Receptor–dependent Mechanisms during Anti-CD20 Antibody Immunotherapy
Duke University · Duke Medical Center · +2 more institutions
Abstract
Anti-CD20 antibody immunotherapy effectively treats non-Hodgkin's lymphoma and autoimmune disease. However, the cellular and molecular pathways for B cell depletion remain undefined because human mechanistic studies are limited. Proposed mechanisms include antibody-, effector cell-, and complement-dependent cytotoxicity, the disruption of CD20 signaling pathways, and the induction of apoptosis. To identify the mechanisms for B cell depletion in vivo, a new mouse model for anti-CD20 immunotherapy was developed using a panel of twelve mouse anti-mouse CD20 monoclonal antibodies representing all four immunoglobulin G isotypes. Anti-CD20 antibodies rapidly depleted the vast majority of circulating and tissue B…
Citation impact
- FWCI
- 29.60
- Percentile
- 100%
- References
- 86
Authors
7- JUJunji UchidaCorresponding
Duke University, Duke Medical Center, Duke University Hospital
- YHYasuhito Hamaguchi
Duke Medical Center, Duke University Hospital
- JAJulie A. Oliver
Duke Medical Center, Duke University Hospital
- JVJeffrey V. Ravetch
Rockefeller University
- JCJonathan C. Poe
Duke Medical Center, Duke University Hospital
Topics & keywords
- Biology
- Immunology
- Antibody
- Immunotherapy
- CD20
- B cell
- Fc receptor
- Antibody-dependent cell-mediated cytotoxicity
- Good health and well-being