Emerging landscape of oncogenic signatures across human cancers

Chris Sander and colleagues have extracted significant functional events from 12 tumor types. Tumors can be classified as being driven largely by either mutation or copy number changes, and, within this division, subclasses of cross-tissue patterns of events are discerned that suggest sets of combinatorial therapies. Cancer therapy is challenged by the diversity of molecular implementations of oncogenic processes and by the resulting variation in therapeutic responses. Projects such as The Cancer Genome Atlas (TCGA) provide molecular tumor maps in unprecedented detail. The interpretation of these maps remains a major challenge. Here we distilled thousands of genetic and epigenetic features altered in cancers…

• EI
  Entertainment Industry Foundation

  Award: SU2C-AACR-DT0209
• NI
  National Institutes of Health

  Awards: U41 HG006623, GM103504, P41 GM103504, U24 CA143840
• SU
  Stand Up To Cancer

  Award: SU2C-AACR-DT0209
• NC
  National Cancer Institute

  Awards: U24 CA143840, CA143840