Phase III Trial in Metastatic Gastroesophageal Adenocarcinoma with Fluorouracil, Leucovorin Plus Either Oxaliplatin or Cisplatin: A Study of the Arbeitsgemeinschaft Internistische Onkologie
Heidelberg University · University Hospital Heidelberg · +1 more institution
Abstract
PURPOSE: This study was designed to compare fluorouracil, leucovorin, and oxaliplatin with fluorouracil, leucovorin, and cisplatin in patients with advanced gastric cancer. PATIENTS AND METHODS: Patients with previously untreated advanced adenocarcinoma of the stomach or esophagogastric junction were randomly assigned to receive either fluorouracil 2,600 mg/m(2) via 24-hour infusion, leucovorin 200 mg/m(2), and oxaliplatin 85 mg/m(2) (FLO) every 2 weeks or fluorouracil 2,000 mg/m(2) via 24-hour infusion, leucovorin 200 mg/m(2) weekly, and cisplatin 50 mg/m(2) every 2 weeks (FLP). The primary end point was progression-free survival (PFS). RESULTS: Two hundred twenty patients (median age, 64 years; metastatic,…
Citation impact
- FWCI
- 35.62
- Percentile
- 100%
- References
- 22
Authors
20- SASalah‐Eddin Al‐BatranCorresponding
Heidelberg University, University Hospital Heidelberg, Krankenhaus Nordwest
- JTJ. T. Hartmann
Heidelberg University, University Hospital Heidelberg, Krankenhaus Nordwest
- SPStephan Probst
Heidelberg University, University Hospital Heidelberg, Krankenhaus Nordwest
- HSHarald Schmalenberg
Heidelberg University, University Hospital Heidelberg, Krankenhaus Nordwest
- SHStephan Hollerbach
Heidelberg University, University Hospital Heidelberg, Krankenhaus Nordwest
Topics & keywords
- Medicine
- Oxaliplatin
- Fluorouracil
- Gastroenterology
- Nausea
- Internal medicine
- Vomiting
- Phases of clinical research
- Good health and well-being