articleCancer ResearchJan 12, 2012BRONZE OA

Exploiting the Mutanome for Tumor Vaccination

JCJohn C. CastleSKSebastian KreiterJDJan DiekmannMLMartin LöwerNVNiels van de Roemer

Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Multiple genetic events and subsequent clonal evolution drive carcinogenesis, making disease elimination with single-targeted drugs difficult. The multiplicity of gene mutations derived from clonal heterogeneity therefore represents an ideal setting for multiepitope tumor vaccination. Here, we used next generation sequencing exome resequencing to identify 962 nonsynonymous somatic point mutations in B16F10 murine melanoma cells, with 563 of those mutations in expressed genes. Potential driver mutations occurred in classical tumor suppressor genes and genes involved in proto-oncogenic signaling pathways that control cell proliferation, adhesion, migration, and apoptosis. Aim1 and Trrap mutations known to be…

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824
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Authors

16

Topics & keywords

Topics
Keywords
  • Immunogenicity
  • Nonsynonymous substitution
  • Biology
  • Epitope
  • Immunotherapy
  • Cancer research
  • Gene
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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