Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
Centro Nacional de Biotecnología · Hammersmith Hospital · +3 more institutions
Abstract
The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector molecule on the cellular response to double-stranded RNA, but it also integrates signals in response to Toll-like receptor activation, growth factors, and diverse cellular stresses. In this review, we provide a detailed picture on how signaling downstream of PKR unfolds and what are the ultimate consequences for the cell fate. PKR activation affects both transcription and translation. PKR phosphorylation of the alpha subunit of eukaryotic initiation factor 2 results in a blockade on translation initiation. However, PKR cannot avoid the…
Citation impact
- FWCI
- 17.04
- Percentile
- 100%
- References
- 413
Authors
7Topics & keywords
- Protein kinase R
- EIF-2 kinase
- Biology
- Cell biology
- Interferon
- Kinase
- Effector
- Transcription factor