Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

Diabetic kidney disease is the leading cause of ESRD, but few biomarkers of diabetic kidney disease are available. This study used gas chromatography-mass spectrometry to quantify 94 urine metabolites in screening and validation cohorts of patients with diabetes mellitus (DM) and CKD(DM+CKD), in patients with DM without CKD (DM-CKD), and in healthy controls. Compared with levels in healthy controls, 13 metabolites were significantly reduced in the DM+CKD cohorts (P≤0.001), and 12 of the 13 remained significant when compared with the DM-CKD cohort. Many of the differentially expressed metabolites were water-soluble organic anions. Notably, organic anion transporter-1 (OAT1) knockout mice expressed a similar…

• VU
  Vanderbilt University
• WO
  Wilhelm och Else Stockmanns Stiftelse
• FT
  Folkhälsanin Tutkimussäätiö
• SF
  Samfundet Folkhälsan
• NI
  National Institutes of Health
• UO
  University of California, San Diego
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases