Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Holmes, Michael V.; Dale, Caroline; Zuccolo, Luisa; Silverwood, Richard J.; Guo, Yanfei; Ye, Z.; Prieto‐Merino, David; Dehghan, Abbas; Trompet, Stella; Wong, Andrew; Cavadino, Alana; Drogan, Dagmar; Padmanabhan, Sandosh; Li, Simon; Yesupriya, Ajay; Leusink, Maarten; Sundström, Johan; Hubáček, Jaroslav A.; Pikhart, Hynek; Swerdlow, Daniel I.; Panayiotou, Andrie G.; Borinskaya, S. A.; Finan, Chris; Shah, Sonia; Kuchenbaecker, Karoline; Shah, Tina; Engmann, Jorgen; Folkersen, Lasse; Eriksson, Per; Ricceri, Fulvio; Melander, Olle; Sacerdote, Carlotta; Gamble, Dale M.; Rayaprolu, Sruti; Ross, Owen A.; McLachlan, S.; Vikhireva, Olga; Sluijs, Ivonne; Scott, R.A.; Adámková, Věra; Flicker, Leon; Bockxmeer, F. M. van; Power, Chris; Marques‐Vidal, Pedro; Meade, T W; Marmot, Michael; Ferro, José M.; Paulos-Pinheiro, S.; Humphries, Steve E.; Talmud, Philippa J.; Leach, Irene Mateo; Verweij, Niek; Linneberg, Allan; Skaaby, Tea; Doevendans, Pieter A.; Cramer, Maarten J.; Harst, Pim van der; Klungel, Olaf H.; Dowling, Nicole F.; Dominiczak, Anna F.; Kumari, Meena; Nicolaides, Andrew; Weikert, Cornelia; Boeing, Heiner; Ebrahim, Shah; Gaunt, Tom R.; Price, Jackie F.; Lannfelt, L.; Peasey, Anne; Kubínová, Růžena; Pajak, A.; Malyutina, Sofia; Voevoda, M. I.; Tamošiūnas, Algirdas; Zee, Anke H. Maitland‐van der; Norman, Paul E.; Hankey, Graeme J.; Bergmann, Michael; Hofman, Amy; Franco, Oscar H.; Cooper, J.; Palmen, Jutta; Spiering, Wilko; Jong, Pim A. de; Kuh, Diana; Hardy, Rebecca; Uitterlinden, André G.; Ikram, M. Arfan; Ford, Ian; Hyppönen, Elina; Almeida, Osvaldo P.; Wareham, Nicholas J.; Khaw, K.-T.; Hamsten, Anders; Husemoen, Lise Lotte N.; Tjønneland, Anne; Tolstrup, Janne Schurmann; Rimm, Eric B.; Beulens, Joline W. J.; Verschuren, W. M. Monique; Onland‐Moret, N. Charlotte; Hofker, Marten H.; Wannamethee, S. Goya; Whincup, Peter H.; Morris, Richard; Vicente, Astrid M.; Watkins, Hugh; Farrall, Martin; Jukema, J. Wouter; Meschia, James F.; Cupples, L. Adrienne; Sharp, Stephen J.; Fornage, M.; Kooperberg, Charles; LaCroix, Andrea Z.; Dai, Jiyan; Lanktree, Matthew B.; Siscovick, David S.; Jorgenson, Eric; Spring, Bonnie; Coresh, Josef; Lange, Leslie A.; Buxbaum, Sarah G.; Schreiner, Pamela J.; Ellison, R. Curtis; Tsai, Michael Y.; Patel, Sanjay R.; Redline, Susan; Johnson, Andrew D.; Hoogeveen, Ron C.; Hakonarson, H.; Rotter, Jerome I.; Boerwinkle, Eric; Bakker, Paul I. W. de; Kivimäki, Mika; Asselbergs, Folkert W.; Sattar, Naveed; Lawlor, Debbie A.; Whittaker, John C.; Smith, George Davey; Mukamal, K.; Psaty, Bruce M.; Wilson, James; Lange, Leslie A.; Hamidovic, Ajna; Hingorani, Aroon D.; Nordestgaard, Børge G.; Bobák, Martin; Leon, David A.; Langenberg, Claudia; Palmer, Tom; Reiner, Alex P.; Keating, Brendan J.; Dudbridge, Frank; Casas, J. P.

doi:10.1136/bmj.g4164

reviewBMJJul 10, 2014HYBRID OA

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

MVMichael V. Holmes CDCaroline Dale LZLuisa Zuccolo RJRichard J. Silverwood YGYanfei Guo

University College London · University of Pennsylvania · +86 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

Objective

To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.

Design

Mendelian randomisation meta-analysis of 56 epidemiological studies.

Citation impact

676

total citations

FWCI: 49.07
Percentile: 100%
References: 41

Citations per year

Authors

155

MV
Michael V. HolmesCorresponding
University College London, University of Pennsylvania
CD
Caroline Dale
London School of Hygiene & Tropical Medicine
LZ
Luisa Zuccolo
MRC Epidemiology Unit
RJ
Richard J. Silverwood
University of London, London School of Hygiene & Tropical Medicine
YG
Yanfei Guo
BGI Group (China), Children's Hospital of Philadelphia

Topics & keywords

Topics

Alcohol Consumption and Health Effects99%
Substance Abuse Treatment and Outcomes0%
Genetic Associations and Epidemiology0%

Keywords

Association (psychology)
Disease
Mendelian inheritance
Mendelian randomization
Medicine
Computer science
Bioinformatics
Data science

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

JD
John D. and Catherine T. MacArthur Foundation
AH
American Heart Association
MF
Mayo Foundation for Medical Education and Research
NU
Northwestern University
CD
Compagnia di San Paolo
WT
Wellcome Trust
NM
Northwestern Memorial Foundation
CR
Cancer Research UK
BH
British Heart Foundation
UC
University College London
EC
European Commission
DF
Deutsche Forschungsgemeinschaft
Z
ZonMw
BF
Bundesministerium für Bildung und Forschung
MD
Ministero della Salute
NO
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
H
Hjärt-Lungfonden
SL
Stockholms Läns Landsting
V
Vetenskapsrådet
DK
Deutsche Krebshilfe
NI
National Institutes of Health
MR
Medical Research Council
Awards: MR/K013351/1, MR/K006584/1, MC_PC_15018, MC_UU_12015/1
EA
Economic and Social Research Council
Awards: ES/I025561/2, ES/F02679X/1, ES/J023299/1, ES/I025561/1, ES/I025561/3
WC
World Cancer Research Fund
NH
National Health and Medical Research Council
AN
Agentschap NL
NI
National Institute on Alcohol Abuse and Alcoholism
NH
National Heart, Lung, and Blood Institute
NI
National Institute on Drug Abuse
NI
National Institute on Minority Health and Health Disparities