Pathogen–Host Interactions in Pseudomonas aeruginosa Pneumonia

Pseudomonas aeruginosa is an important pathogen causing a wide range of acute and chronic infections. P. aeruginosa rarely causes infection in the normal host, but is an efficient opportunistic pathogen causing serious infections in patients who are mechanically ventilated, individuals who are immunocompromised, and patients with malignancies or HIV infection. Among these risk groups, the most vulnerable hosts are neutropenic and patients who are mechanically ventilated. In addition, P. aeruginosa is the most prevalent chronic infection contributing to the pathogenesis of cystic fibrosis. Because of the ubiquitous nature of P. aeruginosa and its ability to develop resistance to antibiotics, it continues to be…

• UD
  U.S. Department of Veterans Affairs
• NI
  National Institutes of Health

  Awards: HL075557, HL61419
• NH
  National Heart, Lung, and Blood Institute

  Award: HL61419