articleScienceNov 4, 2010GREEN OA

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

TIThe International HIV Controllers Study
PubMed
Indexed incrossrefpubmed

Abstract

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain…

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Authors

1
  • TI
    The International HIV Controllers StudyCorresponding

Topics & keywords

Topics
Keywords
  • Human leukocyte antigen
  • Affect (linguistics)
  • Human immunodeficiency virus (HIV)
  • Peptide
  • Presentation (obstetrics)
  • Immunology
  • Genetics
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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