A Neurovascular Niche for Neurogenesis after Stroke
University of California, Los Angeles · University of California San Diego
Abstract
Stroke causes cell death but also birth and migration of new neurons within sites of ischemic damage. The cellular environment that induces neuronal regeneration and migration after stroke has not been defined. We have used a model of long-distance migration of newly born neurons from the subventricular zone to cortex after stroke to define the cellular cues that induce neuronal regeneration after CNS injury. Mitotic, genetic, and viral labeling and chemokine/growth factor gain- and loss-of-function studies show that stroke induces neurogenesis from a GFAP-expressing progenitor cell in the subventricular zone and migration of newly born neurons into a unique neurovascular niche in peri-infarct cortex. Within…
Citation impact
- FWCI
- 14.40
- Percentile
- 100%
- References
- 64
Authors
4Topics & keywords
- Neurogenesis
- Subventricular zone
- Neuroblast
- Neuroscience
- Angiogenesis
- Biology
- Rostral migratory stream
- Regeneration (biology)