reviewNew England Journal of MedicineAug 24, 2005Closed access

Neural Stem Cells and the Origin of Gliomas

NSNader SanaiAÁArturo Álvarez-BuyllaMSMitchel S. Berger

University of California, San Francisco · Neurological Surgery

PubMed
Indexed incrossrefpubmed

Abstract

Little progress has been made in the treatment of gliomas during the past 25 years. One reason is our poor understanding of the cell of origin in these tumors and of the mechanisms that bring that cell into a malignant state. This review argues that gliomas arise from neural stem cells and discusses the clinical implications of this concept.

Citation impact

1,041
total citations
FWCI
22.91
Percentile
100%
References
93
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Medicine
  • Stem cell
  • Neural stem cell
  • Glioma
  • Neuroscience
  • Pathology
  • Cancer research
  • Biology
UN Sustainable Development Goals
  • No poverty
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