Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
University of Southern California · University of Cambridge · +3 more institutions
Abstract
The ventromedial prefrontal cortex (vmPFC) and insular cortex are implicated in distributed neural circuitry that supports emotional decision-making. Previous studies of patients with vmPFC lesions have focused primarily on decision-making under uncertainty, when outcome probabilities are ambiguous (e.g. the Iowa Gambling Task). It remains unclear whether vmPFC is also necessary for decision-making under risk, when outcome probabilities are explicit. It is not known whether the effect of insular damage is analogous to the effect of vmPFC damage, or whether these regions contribute differentially to choice behaviour. Four groups of participants were compared on the Cambridge Gamble Task, a well-characterized…
Citation impact
- FWCI
- 18.15
- Percentile
- 100%
- References
- 74
Authors
6- LCLuke ClarkCorresponding
University of Southern California, University of Cambridge
- ABAntoine Bechara
University of Iowa Hospitals and Clinics, University of Southern California
- HDH. Damasio
University of Southern California
- MRMichael R. F. Aitken
Neuroscience Institute, University of Southern California, University of Cambridge
- BJBarbara J. Sahakian
University of Cambridge, Neuroscience Institute, University of Southern California, Addenbrooke's Hospital
Topics & keywords
- Ventromedial prefrontal cortex
- Insular cortex
- Psychology
- Prefrontal cortex
- Cortex (anatomy)
- Odds
- Neuroscience
- Cognitive psychology
- Peace, Justice and strong institutions