Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic
University of Messina · Lundbeck (Denmark) · +4 more institutions
Abstract
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype-selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and…
Citation impact
- FWCI
- 28.77
- Percentile
- 100%
- References
- 22
Authors
28- MLMarcel LeistCorresponding
University of Messina, Lundbeck (Denmark), Mario Negri Institute for Pharmacological Research, Neuroscience Institute, Early Warning (United States)
- PGPietro GhezziCorresponding
University of Messina, Lundbeck (Denmark), Mario Negri Institute for Pharmacological Research, Neuroscience Institute, Early Warning (United States)
- GGGiovanni Grasso
University of Messina, Lundbeck (Denmark), Mario Negri Institute for Pharmacological Research, Neuroscience Institute, Early Warning (United States)
- RBRoberto Bianchi
University of Messina, Lundbeck (Denmark), Mario Negri Institute for Pharmacological Research, Neuroscience Institute, Early Warning (United States)
- PVPia Villa
University of Messina, Lundbeck (Denmark), Mario Negri Institute for Pharmacological Research, Neuroscience Institute, Early Warning (United States)
Topics & keywords
- Erythropoietin
- Erythropoietin receptor
- Haematopoiesis
- Neuroprotection
- Receptor
- Pharmacology
- Experimental autoimmune encephalomyelitis
- Chemistry