Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation
John Radcliffe Hospital · University of Oxford · +7 more institutions
Abstract
Transcranial direct current stimulation (tDCS) modulates cortical excitability and is being used for human studies more frequently. Here we probe the underlying neuronal mechanisms by measuring polarity-specific changes in neurotransmitter concentrations using magnetic resonance spectroscopy (MRS). MRS provides evidence that excitatory (anodal) tDCS causes locally reduced GABA while inhibitory (cathodal) stimulation causes reduced glutamatergic neuronal activity with a highly correlated reduction in GABA, presumably due to the close biochemical relationship between the two neurotransmitters.
Citation impact
- FWCI
- 17.87
- Percentile
- 100%
- References
- 32
Authors
9- CJCharlotte J. StaggCorresponding
John Radcliffe Hospital
- JGJonathan G. Best
University of Oxford, Wellcome Centre for Integrative Neuroimaging
- MCMary C. Stephenson
University of Nottingham
- JOJacinta O’Shea
University of Oxford, Wellcome Centre for Integrative Neuroimaging
- MWMarzena Wylezinska
University of Oxford, Wellcome Centre for Integrative Neuroimaging, NIHR Imperial Biomedical Research Centre, Imperial College London, Medical Research Council
Topics & keywords
- Neuroscience
- Transcranial direct-current stimulation
- Glutamatergic
- Excitatory postsynaptic potential
- Stimulation
- Inhibitory postsynaptic potential
- Glutamate receptor
- Neurotransmitter
- Good health and well-being