Adult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis
University of California, San Francisco · Neurological Surgery · +1 more institution
Abstract
Ependymal cells on the walls of brain ventricles play essential roles in the transport of CSF and in brain homeostasis. It has been suggested that ependymal cells also function as stem cells. However, the proliferative capacity of mature ependymal cells remains controversial, and the developmental origin of these cells is not known. Using confocal or electron microscopy (EM) of adult mice that received bromodeoxyuridine (BrdU) or [3H]thymidine for several weeks, we found no evidence that ependymal cells proliferate. In contrast, ependymal cells were labeled by BrdU administration during embryonic development. The majority of them are born between embryonic day 14 (E14) and E16. Interestingly, we found that the…
Citation impact
- FWCI
- 9.83
- Percentile
- 100%
- References
- 60
Authors
6- NSNathalie SpasskyCorresponding
University of California, San Francisco, Neurological Surgery
- FTFlorian T. Merkle
University of California, San Francisco, Neurological Surgery
- NFNuria Flames
Universitat de València
- ADAnthony D. Tramontin
University of California, San Francisco, Neurological Surgery
- JMJosé Manuel García‐Verdugo
Universitat de València
Topics & keywords
- Ependymal Cell
- Embryonic stem cell
- Biology
- Cell biology
- Bromodeoxyuridine
- Ependyma
- Neuroglia
- Lateral ventricles