articleJournal of Clinical InvestigationApr 16, 2014BRONZE OA

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

CBClaudia BangSBSándor BátkaiSDSeema DangwalSKShashi Kumar GuptaAFAriana Foinquinos

Medizinische Hochschule Hannover · Translational Therapeutics (United States) · +7 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

In response to stress, the heart undergoes extensive cardiac remodeling that results in cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute to heart failure. Alterations in microRNA (miRNA) levels are associated with dysfunctional gene expression profiles associated with many cardiovascular disease conditions; however, miRNAs have emerged recently as paracrine signaling mediators. Thus, we investigated a potential paracrine miRNA crosstalk between cardiac fibroblasts and cardiomyocytes and found that cardiac fibroblasts secrete miRNA-enriched exosomes. Surprisingly, evaluation of the miRNA content of cardiac fibroblast-derived exosomes revealed a relatively high abundance…

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Topics & keywords

Topics
Keywords
  • Microvesicles
  • Paracrine signalling
  • Cell biology
  • Cardiac fibrosis
  • Biology
  • microRNA
  • Fibrosis
  • Gene silencing
UN Sustainable Development Goals
  • Good health and well-being
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