Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
Mount Sinai Hospital · Icahn School of Medicine at Mount Sinai · +1 more institution
Abstract
Recent epidemiological evidence indicates that insulin resistance, a proximal cause of Type II diabetes [a non-insulin dependent form of diabetes mellitus (NIDDM)], is associated with an increased relative risk for Alzheimer's disease (AD). In this study we examined the role of dietary conditions leading to NIDDM-like insulin resistance on amyloidosis in Tg2576 mice, which model AD-like neuropathology. We found that diet-induced insulin resistance promoted amyloidogenic beta-amyloid (Abeta) Abeta1-40 and Abeta1-42 peptide generation in the brain that corresponded with increased gamma-secretase activities and decreased insulin degrading enzyme (IDE) activities. Moreover, increased Abeta production also…
Citation impact
- FWCI
- 11.30
- Percentile
- 100%
- References
- 51
Authors
12- LHLap HoCorresponding
Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai
- WQWeiping Qin
Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai
- PNPatrick N. Pompl
Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai
- ZXZhongmin Xiang
Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai
- JWJun Wang
Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai
Topics & keywords
- Insulin resistance
- Internal medicine
- Endocrinology
- Insulin-degrading enzyme
- GSK-3
- Protein kinase B
- Glycogen synthase
- Insulin receptor
- Good health and well-being