reviewAnnual Review of PhysiologyFeb 10, 2013GREEN OA

Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism

MCMing Chang HuKSKazuhiro ShiizakiMKMakoto Kuro‐oOWOrson W. Moe

The University of Texas Southwestern Medical Center

PubMed
Indexed incrossrefpubmed

Abstract

The metabolically active and perpetually remodeling calcium phosphate-based endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and phosphate homeostasis that involves multiple organs in terms of mineral flux and endocrine cross talk. The fibroblast growth factor (FGF)-Klotho endocrine networks epitomize the complexity of systems biology, and specifically, the FGF23-αKlotho axis highlights the concept of the skeleton holding the master switch of homeostasis rather than a passive target organ as hitherto conceived. Other than serving as a coreceptor for FGF23, αKlotho circulates as an endocrine substance with a multitude of effects. This review covers recent data on the…

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586
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Authors

4

Topics & keywords

Topics
Keywords
  • Klotho
  • Endocrine system
  • Fibroblast growth factor 23
  • Fibroblast growth factor
  • Homeostasis
  • Biology
  • Endocrinology
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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