reviewAnnual Review of Biophysics and Biomolecular StructureMar 3, 2007Closed access

Microfluidic Large-Scale Integration: The Evolution of Design Rules for Biological Automation

JMJessica MelinSRStephen R. Quake

Howard Hughes Medical Institute · Stanford University

PubMed
Indexed incrossrefpubmed

Abstract

Microfluidic large-scale integration (mLSI) refers to the development of microfluidic chips with thousands of integrated micromechanical valves and control components. This technology is utilized in many areas of biology and chemistry and is a candidate to replace today's conventional automation paradigm, which consists of fluid-handling robots. We review the basic development of mLSI and then discuss design principles of mLSI to assess the capabilities and limitations of the current state of the art and to facilitate the application of mLSI to areas of biology. Many design and practical issues, including economies of scale, parallelization strategies, multiplexing, and multistep biochemical processing, are…

Citation impact

745
total citations
FWCI
33.96
Percentile
100%
References
53
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Microfluidics
  • Automation
  • Scale (ratio)
  • Computer science
  • Nanotechnology
  • Robot
  • Systems engineering
  • Data science
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
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