APP processing in Alzheimer's disease
Xiamen University · Sanford Burnham Prebys Medical Discovery Institute
Abstract
An important pathological feature of Alzheimer's disease (AD) is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides called β-amyloid (Aβ). Multiple lines of evidence demonstrate that overproduction/aggregation of Aβ in the brain is a primary cause of AD and inhibition of Aβ generation has become a hot topic in AD research. Aβ is generated from β-amyloid precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase complex. Alternatively, APP can be cleaved by α-secretase within the Aβ domain to release soluble APPα and preclude Aβ generation. Cleavage of APP by caspases may also contribute to AD…
Citation impact
- FWCI
- 24.57
- Percentile
- 100%
- References
- 215
Authors
4Topics & keywords
- Senile plaques
- Amyloid precursor protein
- Amyloid precursor protein secretase
- Neuroscience
- Alzheimer's disease
- P3 peptide
- Extracellular
- Disease
Funding
- AAAlzheimer's Association
- AHAmerican Health Assistance Foundation
- NNNational Natural Science Foundation of ChinaAwards: 2009ZX09103, 30973150
- FYFok Ying Tung Education Foundation
- NINational Institutes of HealthAwards: R03AG034366, R01AG030197, R01NS046673, R01AG021173
- PFProgram for New Century Excellent Talents in University
- FRFundamental Research Funds for the Central Universities