Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits
National Institute on Aging · University of Michigan · +10 more institutions
Abstract
The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several environmental risk factors, but also of genetic predisposition. To take advantage of recent advances in gene-mapping technology, we executed a genome-wide association scan to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia. Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight. Within the FTO gene, rs9930506 showed the strongest…
Citation impact
- FWCI
- 72.18
- Percentile
- 100%
- References
- 57
Authors
25- ASAngelo Scuteri
National Institute on Aging
- SSSerena Sanna
University of Michigan, Michigan United, Institute of Genetic and Biomedical Research
- WCWei‐Min Chen
University of Michigan, Michigan United
- MUManuela Uda
Institute of Genetic and Biomedical Research
- GAGiuseppe Albai
Institute of Genetic and Biomedical Research
Topics & keywords
- Minor allele frequency
- Single-nucleotide polymorphism
- FTO gene
- Allele
- Genome-wide association study
- Genetic association
- Genetics
- Biology
- Good health and well-being