Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
University of Graz · Research Institute of Molecular Pathology · +1 more institution
Abstract
Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. Here, we report that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. It is interesting that ATGL contains a "patatin domain" common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid…
Citation impact
- FWCI
- 42.05
- Percentile
- 100%
- References
- 23
Authors
11- RZRobert ZimmermannCorresponding
University of Graz, Research Institute of Molecular Pathology, Graz University of Technology
- JGJuliane Gertrude Bogner‐Strauß
University of Graz, Research Institute of Molecular Pathology, Graz University of Technology
- GHGuenter Haemmerle
University of Graz, Research Institute of Molecular Pathology, Graz University of Technology
- GSGabriele Schoiswohl
University of Graz, Research Institute of Molecular Pathology, Graz University of Technology
- RBRuth Birner‐Gruenberger
University of Graz, Research Institute of Molecular Pathology, Graz University of Technology
Topics & keywords
- Adipose triglyceride lipase
- Lipolysis
- Adipose tissue
- Triglyceride
- Perilipin
- Lipase
- Catabolism
- Hormone-sensitive lipase