TGF-β/Smad signaling in renal fibrosis

TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis. TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects. Among them, Smad signaling is recognized as a major pathway of TGF-β signaling in progressive renal fibrosis. During fibrogenesis, Smad3 is highly activated, which is associated with the down-regulation of an inhibitory Smad7 via an ubiquitin E3-ligases-dependent degradation mechanism. The equilibrium shift between Smad3 and Smad7 leads to accumulation and activation of myofibroblasts, overproduction of ECM (extracellular matrix), and reduction in ECM degradation in the diseased kidney. Therefore, overexpression of Smad7 has…

• NN
  National Natural Science Foundation of China

  Award: 81300580
• CU
  Chinese University of Hong Kong
• MS
  Major State Basic Research Development Program of China

  Award: 2012CB517705
• NK
  National Key Research and Development Program of China

  Award: 2012CB517705