The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

Read alignment is an ongoing challenge for the analysis of data from sequencing technologies. This article proposes an elegantly simple multi-seed strategy, called seed-and-vote, for mapping reads to a reference genome. The new strategy chooses the mapped genomic location for the read directly from the seeds. It uses a relatively large number of short seeds (called subreads) extracted from each read and allows all the seeds to vote on the optimal location. When the read length is

• AG
  Australian Government
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council

  Award: 1023454