Derivation of midbrain dopamine neurons from human embryonic stem cells
University of Connecticut · Cornell University · +1 more institution
Abstract
Human embryonic stem (hES) cells are defined by their extensive self-renewal capacity and their potential to differentiate into any cell type of the human body. The challenge in using hES cells for developmental biology and regenerative medicine has been to direct the wide differentiation potential toward the derivation of a specific cell fate. Within the nervous system, hES cells have been shown to differentiate in vitro into neural progenitor cells, neurons, and astrocytes. However, to our knowledge, the selective derivation of any given neuron subtype has not yet been demonstrated. Here, we describe conditions to direct hES cells into neurons of midbrain dopaminergic identity. Neuroectodermal…
Citation impact
- FWCI
- 21.57
- Percentile
- 100%
- References
- 33
Authors
8- ALAnselme L. Perrier
University of Connecticut, Cornell University, Kettering University
- VTViviane Tabar
University of Connecticut, Cornell University, Kettering University
- TBTiziano Barberi
University of Connecticut, Cornell University, Kettering University
- MEMaría E. Rubio
University of Connecticut, Cornell University, Kettering University
- JLJuan L. Brusés
University of Connecticut, Cornell University, Kettering University
Topics & keywords
- Midbrain
- Embryonic stem cell
- Biology
- Neuroscience
- Stem cell
- Cellular differentiation
- Cell biology
- Neuron
- Good health and well-being