reviewJournal of Materials Science Materials in MedicineMay 27, 2014HYBRID OA

Bone substitutes in orthopaedic surgery: from basic science to clinical practice

VCVincenzo CampanaGMGiuseppe MilanoEDE. D. PaganoMBMarta BarbaCCClaudia Cicione

Università Cattolica del Sacro Cuore

PubMed
Indexed incrossrefdoajpubmed

Abstract

Bone substitutes are being increasingly used in surgery as over two millions bone grafting procedures are performed worldwide per year. Autografts still represent the gold standard for bone substitution, though the morbidity and the inherent limited availability are the main limitations. Allografts, i.e. banked bone, are osteoconductive and weakly osteoinductive, though there are still concerns about the residual infective risks, costs and donor availability issues. As an alternative, xenograft substitutes are cheap, but their use provided contrasting results, so far. Ceramic-based synthetic bone substitutes are alternatively based on hydroxyapatite (HA) and tricalcium phosphates, and are widely used in the…

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1,108
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22.69
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100%
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196
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Authors

8

Topics & keywords

Topics
Keywords
  • Nonunion
  • Materials science
  • Bone grafting
  • Mesenchymal stem cell
  • Bone morphogenetic protein
  • Bone healing
  • Regenerative medicine
  • Biomedical engineering
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