Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
McGowan Institute for Regenerative Medicine · Pulmonary and Allergy Associates · +1 more institution
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Abstract
Dendritic cells (DCs) are the most potent APCs. Whereas immature DCs down-regulate T-cell responses to induce/maintain immunologic tolerance, mature DCs promote immunity. To amplify their functions, DCs communicate with neighboring DCs through soluble mediators, cell-to-cell contact, and vesicle exchange. Transfer of nanovesicles (
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17Topics & keywords
Topics
Keywords
- Microvesicles
- Exosome
- Cell biology
- Endocytic cycle
- microRNA
- Biology
- Dendritic cell
- Cell
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