Penicillin-binding proteins and β-lactam resistance
Centre National de la Recherche Scientifique · Université Grenoble Alpes · +4 more institutions
Abstract
A number of ways and means have evolved to provide resistance to eubacteria challenged by beta-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even within this narrow focus, a great variety of strategies have been uncovered such as the acquisition of an additional low-affinity PBP, the overexpression of an endogenous low-affinity PBP, the alteration of endogenous PBPs by point mutations or homologous recombination or a combination of the above.
Citation impact
- FWCI
- 9.33
- Percentile
- 100%
- References
- 291
Authors
3- AZAndré ZapunCorresponding
Centre National de la Recherche Scientifique, Université Grenoble Alpes, Université Joseph Fourier, Institut de Biologie Structurale, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, CEA Grenoble
- CCCarlos Contreras‐Martel
CEA Grenoble, Centre National de la Recherche Scientifique, Université Joseph Fourier, Institut de Biologie Structurale, Commissariat à l'Énergie Atomique et aux Énergies Alternatives
- TVThierry Vernet
Institut de Biologie Structurale, Université Joseph Fourier, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, CEA Grenoble, Université Grenoble Alpes, Centre National de la Recherche Scientifique
Topics & keywords
- Penicillin binding proteins
- Biology
- Penicillin
- Antibiotics
- Homologous recombination
- Point mutation
- Endogeny
- Microbiology