MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells
University of California, Santa Barbara · Bioscience Research
Abstract
MicroRNA dysregulation is observed in different types of cancer. MiR-21 up-regulation has been reported for the majority of cancers profiled to date; however, knowledge is limited on the mechanism of action of miR-21, including identification of functionally important targets that contribute to its proproliferative and antiapoptotic actions. In this study, we show for the first time that miR-21 targets multiple important components of the p53, transforming growth factor-beta (TGF-beta), and mitochondrial apoptosis tumor-suppressive pathways. Down-regulation of miR-21 in glioblastoma cells leads to derepression of these pathways, causing repression of growth, increased apoptosis, and cell cycle arrest. These…
Citation impact
- FWCI
- 17.89
- Percentile
- 100%
- References
- 46
Authors
3Topics & keywords
- microRNA
- Derepression
- Oncogene
- Cell cycle
- Apoptosis
- Biology
- Cancer research
- Suppressor
- Good health and well-being