RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription
University of Vienna · Leipzig University of Applied Sciences · +3 more institutions
Abstract
Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and the associations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides (nt) and whole-cell RNAs less than 200 nt were investigated in this genome-wide study. Subcellular addresses for nucleotides present in detected RNAs were assigned, and their potential processing into short RNAs was investigated. Taken together, these observations suggest a novel role for some unannotated RNAs as primary transcripts for the production of short RNAs. Three potentially functional classes of RNAs have been identified, two of which are syntenically…
Citation impact
- FWCI
- 44.26
- Percentile
- 100%
- References
- 11
Authors
22- PKPhilipp Kapranov
University of Vienna, Leipzig University of Applied Sciences, Fraunhofer Institute for Cell Therapy and Immunology, Affymax (United States), Leipzig University
- JCJill Cheng
University of Vienna, Leipzig University of Applied Sciences, Fraunhofer Institute for Cell Therapy and Immunology, Affymax (United States), Leipzig University
- SDSujit Dike
University of Vienna, Leipzig University of Applied Sciences, Fraunhofer Institute for Cell Therapy and Immunology, Affymax (United States), Leipzig University
- DADavid A. Nix
University of Vienna, Leipzig University of Applied Sciences, Fraunhofer Institute for Cell Therapy and Immunology, Affymax (United States), Leipzig University
- RDRadharani Duttagupta
University of Vienna, Leipzig University of Applied Sciences, Fraunhofer Institute for Cell Therapy and Immunology, Affymax (United States), Leipzig University
Topics & keywords
- Polyadenylation
- Small nucleolar RNA
- Biology
- RNA
- Non-coding RNA
- Long non-coding RNA
- Transcriptome
- Genome