Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
Novartis (Switzerland) · Novartis Institutes for BioMedical Research · +15 more institutions
Abstract
Interleukin-17A (IL-17A) is elaborated by the T helper 17 (T(H)17) subset of T(H) cells and exhibits potent proinflammatory properties in animal models of autoimmunity, including collagen-induced arthritis, experimental autoimmune encephalomyelitis, and experimental autoimmune uveitis. To determine whether IL-17A mediates human inflammatory diseases, we investigated the efficacy and safety of AIN457, a human antibody to IL-17A, in patients with psoriasis, rheumatoid arthritis, and chronic noninfectious uveitis. Patients with chronic plaque-type psoriasis (n = 36), rheumatoid arthritis (n = 52), or chronic noninfectious uveitis (n = 16) were enrolled in clinical trials to evaluate the effects of neutralizing…
Citation impact
- FWCI
- 33.15
- Percentile
- 100%
- References
- 49
Authors
25- WHWolfgang Hueber
Novartis (Switzerland), Novartis Institutes for BioMedical Research
- DDDhavalkumar D. PatelCorresponding
Novartis (Switzerland), Novartis Institutes for BioMedical Research
- TPThaddeus P. Dryja
Novartis (Switzerland), Novartis (United States), Novartis Institutes for BioMedical Research
- AWA. Wright
Novartis (Switzerland)
- ИАИ. А. Королева
Novartis (Switzerland), Novartis (United States), Novartis Institutes for BioMedical Research
Topics & keywords
- Psoriasis
- Rheumatoid arthritis
- Medicine
- Uveitis
- Immunology
- Interleukin 17
- Interleukin
- Antibody
- Good health and well-being