reviewCell Communication and SignalingSep 14, 2015GOLD OA

Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

CLClaudia LennickeJRJette RahnRLRudolf LichtenfelsLALudger A. WessjohannBSBarbara Seliger

Martin Luther University Halle-Wittenberg · Leibniz Institute of Plant Biochemistry

PubMed
Indexed incrossrefdoajpubmed

Abstract

Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called "redox signaling" includes the H2O2-mediated reversible oxidation of redox sensitive cysteine residues in enzymes and transcription factors thereby altering their activities. Depending on its intracellular concentration and localization, H2O2 exhibits either pro- or anti-apoptotic activities. In comparison to normal cells, cancer cells are characterized by an increased H2O2 production rate and an impaired redox balance thereby affecting the microenvironment as well as the anti-tumoral immune response. This article reviews the current knowledge about the intracellular production…

Citation impact

578
total citations
FWCI
11.32
Percentile
100%
References
254
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • Hydrogen peroxide
  • Redox
  • Cell biology
  • Chemistry
  • Signal transduction
  • Biochemistry
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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