Damage‐associated molecular pattern–activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury
Union Hospital · Wuhan Union Hospital · +4 more institutions
Abstract
UNLABELLED: Innate immunity plays a crucial role in the response to sterile inflammation such as liver ischemia/reperfusion (I/R) injury. The initiation of liver I/R injury results in the release of damage-associated molecular patterns, which trigger an innate immune and inflammatory cascade through pattern recognition receptors. Neutrophils are recruited to the liver after I/R and contribute to organ damage and innate immune and inflammatory responses. Formation of neutrophil extracellular traps (NETs) has been recently found in response to various stimuli. However, the role of NETs during liver I/R injury remains unknown. We show that NETs form in the sinusoids of ischemic liver lobes in vivo. This was…
Citation impact
- FWCI
- 15.27
- Percentile
- 100%
- References
- 36
Authors
11- HHHai Huang
Union Hospital, Wuhan Union Hospital, University of Pittsburgh Medical Center, Huazhong University of Science and Technology Hospital, Huazhong University of Science and Technology
- STSamer Tohme
University of Pittsburgh Medical Center
- ABAhmed B. Al‐Khafaji
University of Pittsburgh Medical Center
- STSheng Tai
University of Pittsburgh Medical Center
- PLPatricia Loughran
University of Pittsburgh Medical Center
Topics & keywords
- Neutrophil extracellular traps
- Innate immune system
- TLR4
- Liver injury
- Proinflammatory cytokine
- Inflammation
- TLR9
- HMGB1
- Good health and well-being