The A4 Study: Stopping AD Before Symptoms Begin?

Sperling, Reisa A.; Rentz, Dorene M.; Johnson, Keith A.; Karlawish, Jason; Donohue, Michael; Salmon, David P.; Aisen, Paul

doi:10.1126/scitranslmed.3007941

articleScience Translational MedicineMar 19, 2014GREEN OA

The A4 Study: Stopping AD Before Symptoms Begin?

RAReisa A. Sperling DMDorene M. Rentz KAKeith A. Johnson JKJason Karlawish MDMichael Donohue

Brigham and Women's Hospital · Harvard University · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.

Citation impact

770

total citations

FWCI: 261.31
Percentile: 100%
References: 11

Citations per year

Authors

RA
Reisa A. SperlingCorresponding
Brigham and Women's Hospital, Harvard University
DM
Dorene M. Rentz
Brigham and Women's Hospital, Harvard University
KA
Keith A. Johnson
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital
JK
Jason Karlawish
University of Pennsylvania
MD
Michael Donohue
Alzheimer’s Disease Neuroimaging Initiative

Topics & keywords

Topics

Health Systems, Economic Evaluations, Quality of Life100%
Dementia and Cognitive Impairment Research99%
Parkinson's Disease Mechanisms and Treatments99%

Keywords

Medicine
Intensive care medicine

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