reviewGenes & DevelopmentSep 1, 2010DIAMOND OA

tRNA biology charges to the front

EMEric M. PhizickyAKAnita K. Hopper

University of Rochester Medical Center · University of Rochester · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

TRNA biology has come of age, revealing an unprecedented level of understanding and many unexpected discoveries along the way. This review highlights new findings on the diverse pathways of tRNA maturation, and on the formation and function of a number of modifications. Topics of special focus include the regulation of tRNA biosynthesis, quality control tRNA turnover mechanisms, widespread tRNA cleavage pathways activated in response to stress and other growth conditions, emerging evidence of signaling pathways involving tRNA and cleavage fragments, and the sophisticated intracellular tRNA trafficking that occurs during and after biosynthesis.

Citation impact

772
total citations
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References
387
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Transfer RNA
  • Biology
  • Cleavage (geology)
  • Protein biosynthesis
  • T arm
  • Function (biology)
  • Biosynthesis
  • Cell biology
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