Combined Resistance and Aerobic Exercise Program Reverses Muscle Loss in Men Undergoing Androgen Suppression Therapy for Prostate Cancer Without Bone Metastases: A Randomized Controlled Trial
Edith Cowan University · Sir Charles Gairdner Hospital · +2 more institutions
Abstract
PURPOSE: Androgen suppression therapy (AST) results in musculoskeletal toxicity that reduces physical function and quality of life. This study examined the impact of a combined resistance and aerobic exercise program as a countermeasure to these AST-related toxicities. PATIENTS AND METHODS: Between 2007 and 2008, 57 patients with prostate cancer undergoing AST (commenced > 2 months prior) were randomly assigned to a program of resistance and aerobic exercise (n = 29) or usual care (n = 28) for 12 weeks. Primary end points were whole body and regional lean mass. Secondary end points were muscle strength and function, cardiorespiratory capacity, blood biomarkers, and quality of life. RESULTS: Analysis of…
Citation impact
- FWCI
- 21.08
- Percentile
- 100%
- References
- 44
Authors
5- DADaniel A. GalvãoCorresponding
Edith Cowan University, Sir Charles Gairdner Hospital
- DRDennis R. Taaffe
Edith Cowan University, The University of Queensland, The University of Western Australia, Sir Charles Gairdner Hospital
- NSNigel Spry
Edith Cowan University, Sir Charles Gairdner Hospital
- DJDavid Joseph
Edith Cowan University, The University of Queensland, The University of Western Australia, Sir Charles Gairdner Hospital
- RURobert U. Newton
Edith Cowan University, The University of Queensland, The University of Western Australia, Sir Charles Gairdner Hospital
Topics & keywords
- Medicine
- Lean body mass
- Prostate cancer
- Aerobic exercise
- Cardiorespiratory fitness
- Quality of life (healthcare)
- Adverse effect
- Regimen
- Good health and well-being