Acquired Immunity to Malaria
QIMR Berghofer Medical Research Institute · Eijkman Institute for Molecular Biology · +5 more institutions
Abstract
Naturally acquired immunity to falciparum malaria protects millions of people routinely exposed to Plasmodium falciparum infection from severe disease and death. There is no clear concept about how this protection works. There is no general agreement about the rate of onset of acquired immunity or what constitutes the key determinants of protection; much less is there a consensus regarding the mechanism(s) of protection. This review summarizes what is understood about naturally acquired and experimentally induced immunity against malaria with the help of evolving insights provided by biotechnology and places these insights in the context of historical, clinical, and epidemiological observations. We advocate…
Citation impact
- FWCI
- 54.57
- Percentile
- 100%
- References
- 340
Authors
3- DLDenise L. DoolanCorresponding
QIMR Berghofer Medical Research Institute, Eijkman Institute for Molecular Biology, Nuffield Orthopaedic Centre, University of Oxford, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Oxford University Clinical Research Unit Indonesia, Universitat de Barcelona
- CDCarlota Dobaño
QIMR Berghofer Medical Research Institute, Eijkman Institute for Molecular Biology, Nuffield Orthopaedic Centre, University of Oxford, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Oxford University Clinical Research Unit Indonesia, Universitat de Barcelona
- JKJ. Kevin Baird
QIMR Berghofer Medical Research Institute, Eijkman Institute for Molecular Biology, Nuffield Orthopaedic Centre, University of Oxford, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Oxford University Clinical Research Unit Indonesia, Universitat de Barcelona
Topics & keywords
- Malaria
- Immunity
- Immunology
- Context (archaeology)
- Plasmodium falciparum
- Disease
- Severe Malaria
- Mortality rate
- Good health and well-being