Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
Scripps Research Institute · Max Delbrück Center · +4 more institutions
Abstract
In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells. Reduced Nrg1 expression causes hypomyelination and reduced nerve conduction velocity. Neuronal overexpression of Nrg1 induces hypermyelination and demonstrates that Nrg1 type III is the responsible isoform. We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size.
Citation impact
- FWCI
- 15.07
- Percentile
- 100%
- References
- 36
Authors
10- GMG. MichailovCorresponding
Scripps Research Institute, Max Delbrück Center, Universitätsmedizin Göttingen, Max Planck Institute of Experimental Medicine, University of Göttingen
- MWMichael W. SeredaCorresponding
Scripps Research Institute, Max Planck Society, Max Delbrück Center, Universitätsmedizin Göttingen, Max Planck Institute of Experimental Medicine, University of Göttingen
- BGBastian G. Brinkmann
Scripps Research Institute, Max Delbrück Center, Universitätsmedizin Göttingen, Max Planck Institute of Experimental Medicine, University of Göttingen
- TMTobias M. Fischer
Scripps Research Institute, Max Delbrück Center, Universitätsmedizin Göttingen, Max Planck Institute of Experimental Medicine, University of Göttingen
- BABernhard A. Haug
Scripps Research Institute, Max Delbrück Center, Universitätsmedizin Göttingen, Max Planck Institute of Experimental Medicine, University of Göttingen
Topics & keywords
- Neuregulin 1
- Axon
- Myelin
- Neuregulin
- Nerve conduction velocity
- Gene isoform
- Schwann cell
- Neuroscience