articlemBioNov 20, 2012GOLD OA

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

SVSander van BoheemenMDMiranda de GraafCLChris LauberTMTheo M. BestebroerVSV. Stalin Raj

Erasmus MC · Erasmus University Rotterdam · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

UNLABELLED: A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete genome sequence, genome organization, and expression strategy of HCoV-EMC/2012 and its relation with known coronaviruses. The genome contains 30,119 nucleotides and contains at least 10 predicted open reading frames, 9 of which are predicted to be expressed from a nested set of seven subgenomic mRNAs. Phylogenetic analysis of the replicase gene of coronaviruses with completely sequenced genomes showed that HCoV-EMC/2012 is most closely related to Tylonycteris bat coronavirus HKU4 (BtCoV-HKU4) and Pipistrellus bat coronavirus HKU5 (BtCoV-HKU5),…

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942
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Authors

11

Topics & keywords

Topics
Keywords
  • Betacoronavirus
  • Biology
  • Coronavirus
  • Genome
  • Virology
  • Lineage (genetic)
  • Phylogenetic tree
  • Genetics
UN Sustainable Development Goals
  • Good health and well-being
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