T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells
The University of Sydney · Garvan Institute of Medical Research · +3 more institutions
Abstract
Effector T cell responses have long been viewed in the context of the Th1/Th2 paradigm. Recently, a third major subset of nonpolarized effector T cells that provides help to B cells has been identified. These T cells, termed T follicular helper (T(FH)) cells, home to the B cell areas of secondary lymphoid tissue, through interactions mediated via the chemokine receptor CXCR5 and its ligand CXCL13. Affymetrix microarrays were used to identify transcription factors, cytokines, and cell surface molecules that underlie the differentiation pathways and functional properties of the T(FH) subset. The transcriptional profile of human CXCR5(+) T(FH) cells was compared with that of Th1 and Th2 cells, which enabled the…
Citation impact
- FWCI
- 7.98
- Percentile
- 100%
- References
- 66
Authors
7- TCTatyana ChtanovaCorresponding
The University of Sydney, Garvan Institute of Medical Research, Cooperative Trials Group for Neuro-Oncology
- SGStuart G. Tangye
Centenary Institute
- RNRebecca Newton
Garvan Institute of Medical Research
- NFNita Frank
Millennium Engineering and Integration (United States)
- MRMartin R. Hodge
Millennium Engineering and Integration (United States)
Topics & keywords
- Effector
- BCL6
- Biology
- CXCR5
- Cell biology
- CXCL13
- Interleukin 21
- IL-2 receptor