The endocannabinoid system links gut microbiota to adipogenesis

Obesity is characterised by altered gut microbiota, low-grade inflammation and increased endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota and eCB signalling has yet to be confirmed. Here, we report that gut microbiota modulate the intestinal eCB system tone, which in turn regulates gut permeability and plasma lipopolysaccharide (LPS) levels. The impact of the increased plasma LPS levels and eCB system tone found in obesity on adipose tissue metabolism (e.g. differentiation and lipogenesis) remains unknown. By interfering with the eCB system using CB(1) agonist and antagonist in lean and obese mouse models, we found that the eCB system controls gut permeability and…

• VG
  Västra Götalandsregionen
• FD
  Fonds De La Recherche Scientifique - FNRS
• V
  Vetenskapsrådet
• ID
  Instituto Danone
• FS
  Fonds Spéciaux de Recherche