The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

Frost, Gary; Sleeth, Michelle; Sahuri-Arisoylu, Meliz; Lizarbe, Blanca; Cerdán, Sebastián; Brody, Leigh; Anastasovska, Jelena; Ghourab, Samar; Hankir, Mohammed K.; Zhang, Shuai; Carling, David; Swann, Jonathan R.; Gibson, Glenn R.; Viardot, Alexander; Morrison, Douglas J.; Thomas, E. Louise; Bell, Jimmy D.

doi:10.1038/ncomms4611

articleNature CommunicationsApr 29, 2014HYBRID OA

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

GFGary Frost MSMichelle Sleeth MSMeliz Sahuri-Arisoylu BLBlanca Lizarbe SCSebastián Cerdán

Hammersmith Hospital · MRC London Institute of Medical Sciences · +4 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Increased intake of dietary carbohydrate that is fermented in the colon by the microbiota has been reported to decrease body weight, although the mechanism remains unclear. Here we use in vivo(11)C-acetate and PET-CT scanning to show that colonic acetate crosses the blood-brain barrier and is taken up by the brain. Intraperitoneal acetate results in appetite suppression and hypothalamic neuronal activation patterning. We also show that acetate administration is associated with activation of acetyl-CoA carboxylase and changes in the expression profiles of regulatory neuropeptides that favour appetite suppression. Furthermore, we demonstrate through (13)C high-resolution magic-angle-spinning that (13)C acetate…

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Topics

Keywords

Appetite
Glutamine
Internal medicine
Endocrinology
Chemistry
Glutamate receptor
Carbohydrate
Hypothalamus

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