Complement Factor H Polymorphism in Age-Related Macular Degeneration
Yale University · Emmes (United States) · +2 more institutions
Abstract
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD. Among 116,204 single-nucleotide polymorphisms genotyped, an intronic and common variant in the complement factor H gene (CFH) is strongly associated with AMD (nominal P value
Citation impact
- FWCI
- 290.84
- Percentile
- 100%
- References
- 34
Authors
15- RJRobert J. KleinCorresponding
Yale University, Emmes (United States), National Eye Institute, Rockefeller University
- CJCaroline J. Zeiss
Yale University, Emmes (United States), National Eye Institute, Rockefeller University
- EYEmily Y. Chew
Yale University, Emmes (United States), National Eye Institute, Rockefeller University
- JTJen-Yue Tsai
Yale University, Emmes (United States), National Eye Institute, Rockefeller University
- RSRichard S. Sackler
Yale University, Emmes (United States), National Eye Institute, Rockefeller University
Topics & keywords
- Factor H
- Linkage disequilibrium
- Macular degeneration
- Genetics
- Allele
- Single-nucleotide polymorphism
- Biology
- Complement factor I
- Good health and well-being