Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders
University College Cork · APC Microbiome Institute
Abstract
The emerging links between our gut microbiome and the central nervous system (CNS) are regarded as a paradigm shift in neuroscience with possible implications for not only understanding the pathophysiology of stress-related psychiatric disorders, but also their treatment. Thus the gut microbiome and its influence on host barrier function is positioned to be a critical node within the brain-gut axis. Mounting preclinical evidence broadly suggests that the gut microbiota can modulate brain development, function and behavior by immune, endocrine and neural pathways of the brain-gut-microbiota axis. Detailed mechanistic insights explaining these specific interactions are currently underdeveloped. However, the…
Citation impact
- FWCI
- 32.67
- Percentile
- 100%
- References
- 322
Authors
6- JRJohn R. Kelly
University College Cork, APC Microbiome Institute
- PJPaul J. Kennedy
APC Microbiome Institute, University College Cork
- JFJohn F. Cryan
APC Microbiome Institute, University College Cork
- TGTimothy G. Dinan
APC Microbiome Institute, University College Cork
- GCGerard ClarkeCorresponding
APC Microbiome Institute, University College Cork
Topics & keywords
- Microbiome
- Intestinal permeability
- Gut flora
- Neuroscience
- Gut–brain axis
- Immune system
- Endocrine system
- Barrier function
- Good health and well-being
Funding
- PPfizer
- MJMead Johnson Nutrition
- NANational Alliance for Research on Schizophrenia and DepressionAward: 20771
- SFScience Foundation IrelandAwards: SFI/12/RC/, 20771, SFI/12/RC/2273, 12/RC/2273, HRA_POR/2011/23, 12/RC/
- AMAPC Microbiome InstituteAward: SFI/12/RC/2273
- FFFP7 Food, Agriculture and Fisheries, BiotechnologyAward: 613979