reviewAmerican Journal of EpidemiologyMar 15, 2002Closed access

Apolipoprotein E Polymorphism and Cardiovascular Disease: A HuGE Review

JEJune E. Eichner

University of Oklahoma Health Sciences Center

PubMed
Indexed incrossrefpubmed

Abstract

This review examines the association between the apolipoprotein (apo) var epsilon gene polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and cardiovascular disease. The apo var epsilon gene is located at chromosome 19q13.2. Among the variants of this gene, alleles (*) epsilon2, (*) epsilon3, and (*) epsilon4 constitute the common polymorphism found in most populations. Of these variants, apo (*) epsilon3 is the most frequent (>60%) in all populations studied. The polymorphism has functional effects on lipoprotein metabolism mediated through the hepatic binding, uptake, and catabolism of chylomicrons, chylomicron remnants, very low density lipoprotein (VLDL), and high density…

Citation impact

799
total citations
FWCI
30.49
Percentile
100%
References
83
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • Chylomicron
  • Internal medicine
  • Endocrinology
  • Apolipoprotein B
  • Lipoprotein
  • Very low-density lipoprotein
  • Apolipoprotein E
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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