Metabolic reprogramming: the emerging concept and associated therapeutic strategies
Tokyo Medical and Dental University · Japan Society for the Promotion of Science
Abstract
Tumor tissue is composed of cancer cells and surrounding stromal cells with diverse genetic/epigenetic backgrounds, a situation known as intra-tumoral heterogeneity. Cancer cells are surrounded by a totally different microenvironment than that of normal cells; consequently, tumor cells must exhibit rapidly adaptive responses to hypoxia and hypo-nutrient conditions. This phenomenon of changes of tumor cellular bioenergetics, called "metabolic reprogramming", has been recognized as one of 10 hallmarks of cancer. Metabolic reprogramming is required for both malignant transformation and tumor development, including invasion and metastasis. Although the Warburg effect has been widely accepted as a common feature of…
Citation impact
- FWCI
- 12.74
- Percentile
- 100%
- References
- 89
Authors
1Topics & keywords
- Cancer cell
- Reprogramming
- Tumor microenvironment
- Biology
- Warburg effect
- Anaerobic glycolysis
- Cancer research
- Stromal cell