articleCancer ResearchMay 3, 2012BRONZE OA

Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

NMNathan McDannoldCACostas ArvanitisNVNatalia VykhodtsevaMSMargaret S. Livingstone

Brigham and Women's Hospital · Harvard University

PubMed
Indexed incrossrefpubmed

Abstract

The blood-brain barrier (BBB) prevents entry of most drugs into the brain and is a major hurdle to the use of drugs for brain tumors and other central nervous system disorders. Work in small animals has shown that ultrasound combined with an intravenously circulating microbubble agent can temporarily permeabilize the BBB. Here, we evaluated whether this targeted drug delivery method can be applied safely, reliably, and in a controlled manner on rhesus macaques using a focused ultrasound system. We identified a clear safety window during which BBB disruption could be produced without evident tissue damage, and the acoustic pressure amplitude where the probability for BBB disruption was 50% and was found to be…

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591
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Authors

4

Topics & keywords

Topics
Keywords
  • Microbubbles
  • Medicine
  • Blood–brain barrier
  • Central nervous system
  • Ultrasound
  • Focused ultrasound
  • Drug delivery
  • Neuroscience
UN Sustainable Development Goals
  • Good health and well-being
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