The Role of ABC Transporters in Clinical Practice

Abstract Learning Objectives After completing this course, the reader will be able to: Discuss the function of ABC transporters. Outline the levels of expression of MDR in tumors. Determine the role of P-gp inhibitors in clinical practice. Access and take the CME test online and receive one hour of AMA PRA category 1 credit at CME.TheOncologist.com Drug resistance remains one of the primary causes of suboptimal outcomes in cancer therapy. ATP-binding cassette (ABC) transporters are a family of transporter proteins that contribute to drug resistance via ATP-dependent drug efflux pumps. P-glycoprotein (P-gp), encoded by the MDR1 gene, is an ABC transporter normally involved in the excretion of toxins from cells.…