Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion
Centre National de la Recherche Scientifique · Inserm · +4 more institutions
Abstract
Early local tumor invasion in breast cancer results in a likely encounter between cancer cells and mature adipocytes, but the role of these fat cells in tumor progression remains unclear. We show that murine and human tumor cells cocultivated with mature adipocytes exhibit increased invasive capacities in vitro and in vivo, using an original two-dimensional coculture system. Likewise, adipocytes cultivated with cancer cells also exhibit an altered phenotype in terms of delipidation and decreased adipocyte markers associated with the occurrence of an activated state characterized by overexpression of proteases, including matrix metalloproteinase-11, and proinflammatory cytokines [interleukin (IL)-6, IL-1β]. In…
Citation impact
- FWCI
- 18.88
- Percentile
- 100%
- References
- 41
Authors
14- BDBéatrice Dirat
Centre National de la Recherche Scientifique, Inserm, Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale, Institut Claudius Regaud, Institut Curie
- LBLudivine Bochet
Centre National de la Recherche Scientifique, Inserm, Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale, Institut Claudius Regaud, Institut Curie
- MDMarta Dabek
Centre National de la Recherche Scientifique, Inserm, Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale, Institut Claudius Regaud, Institut Curie
- DDDanièle Daviaud
Centre National de la Recherche Scientifique, Inserm, Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale, Institut Claudius Regaud, Institut Curie
- SDStéphanie Dauvillier
Centre National de la Recherche Scientifique, Inserm, Université Fédérale de Toulouse Midi-Pyrénées, Institut de Pharmacologie et de Biologie Structurale, Institut Claudius Regaud, Institut Curie
Topics & keywords
- Cancer
- Cancer cell
- Cancer research
- Biology
- Adipocyte
- Phenotype
- Tumor microenvironment
- Tumor progression
- Good health and well-being