Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial
Inserm · Université de Versailles Saint-Quentin-en-Yvelines · +4 more institutions
Abstract
BACKGROUND: Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. METHODS AND FINDINGS: A total of 3,274 uncircumcised men, aged 18-24 y, were randomized to a control or an intervention group with follow-up visits at months 3, 12, and 21. Male circumcision was offered to the intervention group immediately after randomization and to the control group at the end of the follow-up. The grouped censored data were analyzed in intention-to-treat, univariate and multivariate, analyses, using piecewise exponential, proportional hazards models. Rate…
Citation impact
- FWCI
- 108.77
- Percentile
- 100%
- References
- 38
Authors
6- BABertran AuvertCorresponding
Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Laboratoire d'études sur les monothéismes, Hôpital Ambroise-Paré, Hôpitaux de Saint Maurice
- DTDirk Taljaard
- ELEmmanuel Lagarde
Inserm, Laboratoire d'études sur les monothéismes, Hôpitaux de Saint Maurice
- JSJoëlle Sobngwi-Tambekou
Inserm, Hôpitaux de Saint Maurice
- RSRémi Sitta
Inserm, Laboratoire d'études sur les monothéismes, Hôpitaux de Saint Maurice
Topics & keywords
- Medicine
- Randomized controlled trial
- Male circumcision
- Human immunodeficiency virus (HIV)
- Clinical trial
- Population
- Internal medicine
- Family medicine
- Good health and well-being